Soluble serum ACE originates from endothelial cells by proteolytic cleavage by an unidentified protease of the Arg–Ser peptide bond in the stalk region near the C-terminal transmembrane sequence of the ACE molecule

References 1. Jin G, Tengvall P, Lundström I, Arwin H. A biosensor concept based imaging ellipsometry for visualization of biomolecular interactions. Anal Biochem 1995;232:69–72. 2. Jin G, Jansson R, Arwin H. Imaging ellipsometry revisited: developments for visulization of thin transparent layers on silicon substrates. Rev Sci Instrum 1996;67:2930–6. 3. Wang Z, Jin G. A label-free multisensing immunosensor based on imaging ellipsometry. Anal Chem 2003;75:6119–23. 4. Handley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29–36. 5. Kurebayashi J, Yamamoto Y, Tanaka K, Kohno N, Kurosumi M, Moriya T, et al. Significance of serum carcinoembryonic antigen and CA15-3 in monitoring advanced breast cancer patients treated with systemic therapy: a large-scale retrospective study. Breast Cancer 2003;10:38–44. 6. Clinton SR, Beason KL, Johnson JT, Jackson M, Wilson C, Holifield K, et al. A comparative study of four serological tumor markers for the detection of breast cancer. Biomed Sci Instrum 2003;39:408–14. 7. Zhang HG, Xiu RJ. Micro-vascular medicine and proteomics [Review]. Clin Hemorheol Microcirc 2003;29:189–92.